What are the cons of LBC

Thin-layer cytology / LBC

Thin-layer cytology / LBC (liquid based cytology) is a test for cancer prevention. This test is used for the early detection of cervical cancer (cervical carcinoma).
Thin-layer cytology is the first significant improvement of the Pap test in 50 years.

This test was developed to reduce the problems and potential for errors that occur with the conventional Pap test (named after the Greek doctor Dr. Papanicolaou).

He provides the first decisive technical improvement or further development of the conventional Pap test. With thin-layer cytology, more meaningful smear material can be obtained. -> Optimal possibility to recognize pathological changes as early as possible. The procedure used here is also referred to as thin-layer cytology or liquid-based cytology.

Thin-layer cytology / LBC (liquid based cytology) is a further development of the conventional Pap test. In this procedure, the cells are wiped off the cervix with a suitable removal device, e.g. a cervix brush, and then transferred to a container with preservation solution. The cell material is preserved and sent to the cytological laboratory.


in the laboratory the cells obtained are processed with a special device. A filtration process distributes, cleans and randomizes the cells. These are then in an evenly thin layer (Thin-layer cytology) on an appropriately prepared slide.

The cells are then stained according to Papanicolaou and assessed under the microscope.


Advantages compared to the conventional smear method:

Almost 100% of the cell material obtained ends up in the liquid and thus high-quality and representative cell material is available for the subsequent microscopic assessment.

This method is standardized, randomized and has also been approved by the FDA (food and drug association).

Accompanying factors such as mucus, blood and detritus are largely dissolved by the liquid and do not interfere with the assessment. The cells can therefore be assessed much better, and conspicuous cells are clearly shown. The number of cell patterns that are difficult or impossible to assess due to superimposed accompanying factors decreases.
Optimal possibility to recognize pathological changes as early as possible.

In the event of diagnostic uncertainties, further, representative thin-layer preparations (up to 5 pieces) can be made from the existing preservation solution.

Other important additional examinations can be carried out without the patient having to visit the gynecologist again:
HPV hybridization test, HPV typing, immunocytochemical examinations-p16 / Ki-67 and detection of chlamydia.


Computer-assisted screening is possible and offers a further increase in quality. In the practice of Dr. Edith Beck has been diagnosed with computer assistance since October 2009.

The pictures below illustrate the technical improvement of the thin-film process compared to conventional technology

conventional: cells in the conventional cancer smear may overlap or be covered with blood and mucus. This makes the assessment more difficult.

Thin Prep: A ThinPrep® slide is pure and clear. The cells are optimally preserved and thus make the diagnosis easier for the cytological assessor.

The patient's name and date of birth must be noted on the oversand jar. An attached examination order is filled out and brought to the cytological practice with the sample. This is done either by post, by pick-up service or by handing it over in person.