What are the medical uses of tamoxifen
Synonym: (Z) -2- [4- (1,2-Diphenylbut-1-enyl) phenoxy] -N, N-dimethylethylamine
Trade name: Ebefen®, Mandofen®, Nolvadex® i.a.
Tamoxifen is a drug that belongs to the selective estrogen receptor modulators (SERM) and is mainly used to treat breast cancer.
Tamoxifen has the molecular formula C.26H29NO and a molar mass of 371.51 g mol-1. The melting point is 97 ° C.
3 Mechanism of Action
Tamoxifen blocks the cytoplasmic estrogen receptors via competitive inhibition, which leads to a reduction in cell division activity in estrogen-dependent tissues. The drug therefore acts as a cytostatic agent.
The prodrug tamoxifen is mainly metabolized by CYP3A4 to N-desmethyl tamoxifen and then by CYP2D6 to 4-hydroxy-N-desmethyl tamoxifen (endoxifen) and thereby activated. The metabolites show an increased affinity for estrogen receptors compared to tamoxifen. If polymorphisms of the CYP-2D6 gene are present, the patient's response to tamoxifen therapy will therefore vary.
Tamoxifen is used primarily for hormone-receptor-positive breast cancer as adjuvant therapy after primary therapy and for the treatment of metastatic breast cancer. Further areas of application are:
6 dosage form
Tamoxifen is administered orally in the form of film-coated tablets and tablets.
7 side effects
The following side effects have been associated with tamoxifen:
Reversible retinopathy or cataracts can rarely occur.
The administration of tamoxifen is contraindicated in children, during pregnancy and in nursing mothers.
10 Regulation notice
Tamoxifen requires a prescription.
- Regierer, Anne C. / Bolbrinker, Juliane / Possinger, K .: Individualization of systemic therapy for breast cancer. In: Der Bayerische Internist 29 (2009). H.3, pp.141-144.
- Shang Y1: Molecular mechanisms of estrogen and SERMs in endometrial carcinogenesis. Nat Rev Cancer. 2006 May; 6 (5): 360-8.
- Shapiro, CL., Law, A .: Side effects of adjuvant treatment of breast cancer. N Engl J Med. 2001 Jun 28; 344 (26)
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