What is potassium chloride in?
Potassium Chloride Package Insert
Potassium chloride solution 7.46% concentrate for infusion
1 What is potassium chloride solution 7.46% and what is it used for?
Substance or indication group
Electrolyte concentrate. 1 ml contains: K + 1 mmol Cl- 1 mmol
Potassium deficiency, especially in hypochloraemic alkalosis.
2 What should be considered before using potassium chloride solution 7.46%?
Absolute contraindications: Increased potassium content in the blood (exception: diabetic coma).
Relative contraindications: disorders of kidney function. Beware of hyperchloremia.
Precautions for use and warnings
Checks of the serum ionogram and the acid-base balance are required. Attention should be paid to intravenous use, as paravenous administration can lead to higher levels of necrosis. The infusion of potassium as part of corrective therapy should generally only be carried out with the help of infusion pumps.
Interactions with other drugs
Potassium-sparing diuretics and aldosterone antagonists, together with potassium chloride, can lead to increased potassium levels in the blood (hyperkalemia). If Suxamethonium and potassium are given at the same time, considerable hyperkalemia can be triggered, which in turn can have a negative effect on the heart rhythm.
pregnancy and breast feeding period
There are no concerns about use during pregnancy and breastfeeding if indicated.
3 How should potassium chloride solution 7.46% be used?
The dosage is based on the analysis values of the serum ionogram and the acid-base status. A potassium deficit is calculated using the following formula: Potassium deficit (mmol) = kg body weight x 0.2 x 2 (4.5 - serum potassium) (the extracellular volume is calculated from body weight in kg x 0.2).
Maximum infusion rate: 20 mmol K + per hour (corresponding to approx. 0.3 mmol K + / kg body weight / hour).
Maximum daily dose: 2-3 mmol K + / kg body weight / day.
type of application
The concentrate must not be used undiluted, but only as an additive to infusion solutions.
Overdosing can lead to an increased level of potassium in the blood (hyperkalaemia), especially with simultaneous acidosis or renal insufficiency. Symptoms of an increased potassium content are weakness, symptoms of paralysis and, above all, cardiovascular disorders with typical changes in the ECG. In severe hyperkalemia, cardiac arrhythmias, ventricular fibrillation and cardiac arrest can occur.
Therapy: slowly infuse 10% calcium gluconate solution intravenously, infusion of glucose with insulin, increase in diuresis. Use of cation exchangers, if necessary acidosis compensation with sodium hydrogen carbonate. If there is a vital indication, dialysis is required. If you have any questions about the use of the drug, the doctor or pharmacist should be consulted.
4 What side effects are possible?
The following can occur as side effects:
- Cardiac arrhythmia if the infusion is too fast.
Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or nurse. This also applies to side effects not listed in this leaflet. You can also report side effects directly to the Federal Institute for Drugs and Medical Devices, Dept. Pharmacovigilance, Kurt-Georg-Kiesinger-Allee 3, D-53175 Bonn, website: www.bfarm.de. By reporting side effects you can help provide more information on the safety of this medicine.
Additional note for specialist groups:
Reporting suspected side effects
Reporting suspected side effects after approval is of great importance. It enables continuous monitoring of the benefit-risk balance of the medicinal product. Healthcare professionals are requested to report any suspected side effects to the Federal Institute for Drugs and Medical Devices, Department of Pharmacovigilance, Kurt-Georg-Kiesinger Allee 3, D-53175 Bonn, website: www.bfarm.de.
5 How should potassium chloride solution 7.46% be stored?
Do not use after the expiry date stated on the container and the outer packaging! Keep medicines out of the reach of children! Use immediately after opening the container! Use only clear solutions in undamaged containers.
6 Further information
1000 ml contain: Medicinally active ingredients: Potassium chloride 74.56 g Other ingredients: Water for injections Theor. Osmolarity: 2000 mOsm / l pH value: 4.5 - 7.5
Dosage form: concentrate for infusion. Glass bottle of 50, 100 and 250 ml.
Marketing Authorization Holder / Manufacturer
SERAG-WIESSNER GmbH & Co. KG
For bullet trap 8 - 12
Telephone (0 92 82) 93 70
Fax (0 92 82) 937 93 69
SERAG-WIESSNER GmbH & Co. KG
7 Price Comparison - Potassium Chloride
Potassium chloride price comparison
For the purchase, we recommend the pharmacy price comparison Sparmedo.de. There the prices of over 70 certified mail-order pharmacies are compared, which means that potassium chloride can be ordered cheaply.Compare prices
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